Chromosome Missegregation Triggers Tumor Cell Pyroptosis and Enhances Anti‐Tumor Immunotherapy in Colorectal Cancer

Chromosome Missegregation Triggers Tumor Cell Pyroptosis and Enhances Anti‐Tumor Immunotherapy in Colorectal Cancer

Abstract Immune checkpoint inhibitor (ICI) therapy is a promising anti‐tumor therapeutic strategy; however, its efficacy in solid tumors is limited. Chromosome missegregation is common in various solid tumors; however, its role in tumor progression remains poorly understood, and its correlation with...

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Bibliographic Details
Main Authors: Wei Duan, Rendy Hosea, Lingxian Wang, Cao Ruan, Fuqiang Zhao, Jingyi Liu, Hezhao Zhao, Makoto Miyagishi, Shourong Wu, Vivi Kasim
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
anti‐tumor immunotherapy
CD8+ T cell
chromosome missegregation
cytosolic dsDNA response
micronucleus
pyroptosis
Online Access:https://doi.org/10.1002/advs.202409769
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https://doi.org/10.1002/advs.202409769

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