Cost-effective promoter methylation analysis via target long-read bisulfite sequencing: a case study in severe preterm birth

Cost-effective promoter methylation analysis via target long-read bisulfite sequencing: a case study in severe preterm birth

Abstract Background DNA methylation plays a critical role in the dynamics of gene expression regulation and the development of various disorders. Whole-genome bisulfite sequencing can provide single-base resolution of CpG methylation levels and is the “gold standard” for DNA methylation quantificati...

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Bibliographic Details
Main Authors: Silvana Pereyra, Angela Sardina, Rita Neumann, Celia May, Rossana Sapiro, Bernardo Bertoni, Mónica Cappetta
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medical Genomics
Subjects:
Target sequencing
Preterm birth
DNA methylation
Gene promoter
long-read sequencing
Online Access:https://doi.org/10.1186/s12920-025-02193-6
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https://doi.org/10.1186/s12920-025-02193-6

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