Three new spirocyclic terpenoids from Euphorbia amygdaloides exhibit cytotoxicity against cancerous cell lines through early and late apoptosis

Three new spirocyclic terpenoids from Euphorbia amygdaloides exhibit cytotoxicity against cancerous cell lines through early and late apoptosis

Bioassay-guided fractionation led to the isolation of three new spirocyclic terpenoid compounds from Euphorbia amygdaloides L., named Zagrosin I–III. Their structures were identified by 1D and 2D NMR (1H NMR, 13C NMR, DEPT 135, HMBC, and HSQC-TOCSY) and LC-MS-MS spectrometry. The cytotoxicity of the...

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Bibliographic Details
Main Authors: Ardalan Pasdaran, Negar Azarpira, Mahdokht Hossein Aghdaie, Maryam Zare, Negin Sheidaie, Fatemeh Hajeb Fard, Azadeh Hamedi
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Arabian Journal of Chemistry
Subjects:
Spirocyclic terpene
Cytotoxicity
Euphorbiaceae
Flow cytometry
Cell cycle analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535224004519
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