Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway

Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway

ObjectiveTetramethylpyrazine (TMPZ), an active alkaloid derived from traditional Chinese medicine, has shown anti-inflammatory and anti-pyroptotic properties. However, its role in acute pancreatitis (AP)-induced pyroptosis remains unclear. This study aims to investigate the effects of TMPZ on AP-ind...

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Bibliographic Details
Main Authors: Huangen Li, Yi Gao, Minglian Huang, Hongling Zhang, Qingqing Wu, Youpei Huang, Xiaotong Ye, Weiwen Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
active alkaloid
anti-inflammatory
anti-pyroptotic
NLRP3 inflammasome
nuclear factor erythroid 2-related factor 2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1557681/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1557681/full

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