HYAL1 deficiency attenuates lipopolysaccharide-triggered renal injury and endothelial glycocalyx breakdown in septic AKI in mice

HYAL1 deficiency attenuates lipopolysaccharide-triggered renal injury and endothelial glycocalyx breakdown in septic AKI in mice

Background Renal dysfunction and disruption of renal endothelial glycocalyx are two important events during septic acute kidney injury (AKI). Here, the role and mechanism of hyaluronidase 1 (HYAL1) in regulating renal injury and renal endothelial glycocalyx breakdown in septic AKI were explored for...

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Bibliographic Details
Main Authors: Hongxia Xing, Shensen Li, Yongchao Fu, Xin Wan, Annan Zhou, Feifei Cao, Qing Sun, Nana Hu, Mengqing Ma, Wenwen Li, Changchun Cao
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Renal Failure
Subjects:
HYAL1
AMPK/mTOR signaling
acute kidney injury
endothelial glycocalyx
autophagy
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2023.2188966
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https://www.tandfonline.com/doi/10.1080/0886022X.2023.2188966

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