An integrated approach based on FDA adverse event reporting system, network pharmacology, molecular docking, and molecular dynamics simulation analysis to study the cardiac adverse reactions and mechanism of action of osimertinib

An integrated approach based on FDA adverse event reporting system, network pharmacology, molecular docking, and molecular dynamics simulation analysis to study the cardiac adverse reactions and mechanism of action of osimertinib

ObjectivesThis study investigates osimertinib-induced cardiac adverse reactions (CAR) using real-world FDA Adverse Event Reporting System (FAERS) data and explores molecular mechanisms via network pharmacology, molecular docking, and dynamics simulations.MethodsWe analyzed osimertinib-related advers...

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Bibliographic Details
Main Authors: Wenjuan Wang, Hong Liu, Yongqing Wen, Yanhua Zhang, Xu Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
osimertinib
adverse event reporting system
molecular docking
network pharmacology
molecular dynamics simulations
cardiac adverse reactions
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1619517/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1619517/full

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