Integrated in-silico design and in vivo validation of multi-epitope vaccines for norovirus

Integrated in-silico design and in vivo validation of multi-epitope vaccines for norovirus

Abstract Background Norovirus (NoVs) is a foodborne pathogen that causes acute gastroenteritis. The diversity of its principal antigenic protein poses a significant challenge to vaccine development and the prevention of large-scale outbreaks globally. Currently, no licensed vaccines against noroviru...

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Main Authors: Jingxuan Qiu, Yiwen Wei, Jiayi Shu, Wenjing Zheng, Yuxi Zhang, Junting Xie, Dong Zhang, Xiaochuan Luo, Xiulan Sun, Xin Wang, Sijie Wang, Xuanyi Wang, Tianyi Qiu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Virology Journal
Subjects:
Norovirus
Multi-epitopes vaccine
Broad-spectrum
B-cell spatial epitope
T-cell epitope
Online Access:https://doi.org/10.1186/s12985-025-02796-6
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https://doi.org/10.1186/s12985-025-02796-6

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