An orally-administered nanotherapeutics with gold nanospheres supplying for rheumatoid arthritis therapy by re-shaping gut microbial tryptophan metabolism

An orally-administered nanotherapeutics with gold nanospheres supplying for rheumatoid arthritis therapy by re-shaping gut microbial tryptophan metabolism

Abstract Dysbiosis of gut microbiota significantly exacerbates the progression of rheumatoid arthritis (RA). Targeting gut microbiota may present a promising therapeutic strategy for RA. Gold nanospheres (GNS), known for excellent biocompatibility, stability and minimal toxicity, have emerged as pre...

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Bibliographic Details
Main Authors: Chuan Yang, Langlang Xie, Zihan Deng, Hongbo Ai, Tingwen Xiang, Xiaojing Yan, Zhiguo Ling, Shiyu Xiao, Yong Tang, Gang Huang, Fei Luo, Yueqi Chen
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Rheumatoid arthritis (RA)
Gold nanospheres (GNS)
Gut microbiota
Tryptophan metabolism
Fibroblast-like synoviocytes (FLSs)
Online Access:https://doi.org/10.1186/s12951-025-03450-7
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https://doi.org/10.1186/s12951-025-03450-7

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