Reprogramming the Tumor Immune Microenvironment with ICAM‐1‐Targeted Antibody‒Drug Conjugates and B7‐H3‐CD3 Bispecific Antibodies

Reprogramming the Tumor Immune Microenvironment with ICAM‐1‐Targeted Antibody‒Drug Conjugates and B7‐H3‐CD3 Bispecific Antibodies

Abstract Reprogramming the tumor immune microenvironment (TIM) plays an important role in promoting the reversal of immune “cold” tumors into “hot” inflammatory tumors. Improving drug targeting, blocking immune checkpoints, and promoting the activation of immune cells are crucial for reprogramming t...

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Bibliographic Details
Main Authors: Shoubing Zhou, Mengyu Hong, Dan Zhao, Wenyu Li, Xiaolong Yuan, Yinghong Wang, Hualong Li, Yang Yang, Tengchuan Jin, Jing Pan
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
antibody‒drug conjugates
B7‐H3‐CD3
ICAM‐1
triple‐negative breast cancer, tumor immune microenvironment
Online Access:https://doi.org/10.1002/advs.202415577
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https://doi.org/10.1002/advs.202415577

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