An Investigation into the Effect of Maltitol, Sorbitol, and Xylitol on the Formation of Carbamazepine Solid Dispersions Through Thermal Processing

An Investigation into the Effect of Maltitol, Sorbitol, and Xylitol on the Formation of Carbamazepine Solid Dispersions Through Thermal Processing

<b>Background:</b> Carbamazepine (CBZ) is a Biopharmaceutical Classification System (BCS) class II drug, that is practically insoluble in water, influencing the oral bioavailability. Polyols are highly hydrophilic crystalline carriers studied for their success in developing solid dispers...

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Bibliographic Details
Main Authors: Madan Sai Poka, Marnus Milne, Anita Wessels, Marique Aucamp
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
Subjects:
carbamazepine
polyols
solid dispersions
polymorphic forms
aqueous solubility
dissolution enhancement
Online Access:https://www.mdpi.com/1999-4923/17/3/321
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