Novel <sup>177</sup>Lu-Labeled [Thz<sup>14</sup>]Bombesin(6–14) Derivatives with Low Pancreas Accumulation for Targeting Gastrin-Releasing Peptide Receptor-Expressing Cancer

Novel <sup>177</sup>Lu-Labeled [Thz<sup>14</sup>]Bombesin(6–14) Derivatives with Low Pancreas Accumulation for Targeting Gastrin-Releasing Peptide Receptor-Expressing Cancer

<b>Background/Objectives:</b> Gastrin-releasing peptide receptor is a promising target for cancer diagnosis and therapy. However, the high pancreas uptake of reported GRPR-targeted radioligands limits their clinical applications. Our group previously reported one <sup>68</sup>...

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Bibliographic Details
Main Authors: Lei Wang, Devon E. Chapple, Hsiou-Ting Kuo, Sara Kurkowska, Ryan P. Wilson, Wing Sum Lau, Pauline Ng, Carlos Uribe, François Bénard, Kuo-Shyan Lin
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceuticals
Subjects:
gastrin-releasing peptide receptor
single-photon emission computed tomography
lutetium-177
dosimetry
radioligand therapy
Online Access:https://www.mdpi.com/1424-8247/18/4/449
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