A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

Abstract The search for new approaches in cancer therapy requires a mechanistic understanding of cancer vulnerabilities and anti-cancer drug mechanisms of action. Problematically, some effective therapeutics target cancer vulnerabilities that have poorly defined mechanisms of anti-cancer activity. O...

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Main Authors: Alex Y. Ge, Abolfazl Arab, Raymond Dai, Albertas Navickas, Lisa Fish, Kristle Garcia, Hosseinali Asgharian, Jackson Goudreau, Sean Lee, Kathryn Keenan, Melissa B. Pappalardi, Michael T. McCabe, Laralynne Przybyla, Hani Goodarzi, Luke A. Gilbert
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-77314-9
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https://doi.org/10.1038/s41598-024-77314-9

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