Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major.

Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major.

Interconversion of UDP-glucose (UDP-Glc) and UDP-galactose (UDP-Gal) by the UDP-Glc 4´-epimerase intimately connects the biosynthesis of these two nucleotide sugars. Their de novo biosynthesis involves transformation of glucose-6-phosphate into glucose-1-phosphate by the phosphoglucomutase and subse...

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Bibliographic Details
Main Authors: Sebastian Damerow, Carolin Hoppe, Giulia Bandini, Patricia Zarnovican, Falk F R Buettner, Carsten G K Lüder, Michael A J Ferguson, Françoise H Routier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-11-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0004205
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https://doi.org/10.1371/journal.pntd.0004205

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