Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats
Preservation of myocardial perfusion during surgery is particularly important in patients with increased risk for perioperative complications, such as diabetes. Volatile anesthetics, like sevoflurane, have cardiodepressive effects and may aggravate cardiovascular complications. We investigated the e...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5205631 |
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| author | Charissa E. van den Brom Chantal A. Boly Carolien S. E. Bulte Rob F. P. van den Akker Rick F. J. Kwekkeboom Stephan A. Loer Christa Boer R. Arthur Bouwman |
| author_facet | Charissa E. van den Brom Chantal A. Boly Carolien S. E. Bulte Rob F. P. van den Akker Rick F. J. Kwekkeboom Stephan A. Loer Christa Boer R. Arthur Bouwman |
| author_sort | Charissa E. van den Brom |
| collection | DOAJ |
| description | Preservation of myocardial perfusion during surgery is particularly important in patients with increased risk for perioperative complications, such as diabetes. Volatile anesthetics, like sevoflurane, have cardiodepressive effects and may aggravate cardiovascular complications. We investigated the effect of sevoflurane on myocardial perfusion and function in prediabetic rats. Rats were fed a western diet (WD; n=18) or control diet (CD; n=18) for 8 weeks and underwent (contrast) echocardiography to determine perfusion and function during baseline and sevoflurane exposure. Myocardial perfusion was estimated based on the product of microvascular filling velocity and blood volume. WD-feeding resulted in a prediabetic phenotype characterized by obesity, hyperinsulinemia, hyperlipidemia, glucose intolerance, and hyperglycemia. At baseline, WD-feeding impaired myocardial perfusion and systolic function compared to CD-feeding. Exposure of healthy rats to sevoflurane increased the microvascular filling velocity without altering myocardial perfusion but impaired systolic function. In prediabetic rats, sevoflurane did also not affect myocardial perfusion; however, it further impaired systolic function. Diet-induced prediabetes is associated with impaired myocardial perfusion and function in rats. While sevoflurane further impaired systolic function, it did not affect myocardial perfusion in prediabetic rats. Our findings suggest that sevoflurane anesthesia leads to uncoupling of myocardial perfusion and function, irrespective of the metabolic state. |
| format | Article |
| id | doaj-art-5007818667f7463b99562079d38e91f8 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-5007818667f7463b99562079d38e91f82025-02-03T06:08:21ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/52056315205631Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic RatsCharissa E. van den Brom0Chantal A. Boly1Carolien S. E. Bulte2Rob F. P. van den Akker3Rick F. J. Kwekkeboom4Stephan A. Loer5Christa Boer6R. Arthur Bouwman7Department of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, NetherlandsDepartment of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, NetherlandsDepartment of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, NetherlandsDepartment of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, NetherlandsLaboratory for Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, NetherlandsDepartment of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, NetherlandsDepartment of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, NetherlandsDepartment of Anesthesiology, VU University Medical Center, Boelelaan 1117, 1081 HV Amsterdam, NetherlandsPreservation of myocardial perfusion during surgery is particularly important in patients with increased risk for perioperative complications, such as diabetes. Volatile anesthetics, like sevoflurane, have cardiodepressive effects and may aggravate cardiovascular complications. We investigated the effect of sevoflurane on myocardial perfusion and function in prediabetic rats. Rats were fed a western diet (WD; n=18) or control diet (CD; n=18) for 8 weeks and underwent (contrast) echocardiography to determine perfusion and function during baseline and sevoflurane exposure. Myocardial perfusion was estimated based on the product of microvascular filling velocity and blood volume. WD-feeding resulted in a prediabetic phenotype characterized by obesity, hyperinsulinemia, hyperlipidemia, glucose intolerance, and hyperglycemia. At baseline, WD-feeding impaired myocardial perfusion and systolic function compared to CD-feeding. Exposure of healthy rats to sevoflurane increased the microvascular filling velocity without altering myocardial perfusion but impaired systolic function. In prediabetic rats, sevoflurane did also not affect myocardial perfusion; however, it further impaired systolic function. Diet-induced prediabetes is associated with impaired myocardial perfusion and function in rats. While sevoflurane further impaired systolic function, it did not affect myocardial perfusion in prediabetic rats. Our findings suggest that sevoflurane anesthesia leads to uncoupling of myocardial perfusion and function, irrespective of the metabolic state.http://dx.doi.org/10.1155/2016/5205631 |
| spellingShingle | Charissa E. van den Brom Chantal A. Boly Carolien S. E. Bulte Rob F. P. van den Akker Rick F. J. Kwekkeboom Stephan A. Loer Christa Boer R. Arthur Bouwman Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats Journal of Diabetes Research |
| title | Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats |
| title_full | Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats |
| title_fullStr | Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats |
| title_full_unstemmed | Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats |
| title_short | Myocardial Perfusion and Function Are Distinctly Altered by Sevoflurane Anesthesia in Diet-Induced Prediabetic Rats |
| title_sort | myocardial perfusion and function are distinctly altered by sevoflurane anesthesia in diet induced prediabetic rats |
| url | http://dx.doi.org/10.1155/2016/5205631 |
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