A holistic rat model to investigate therapeutic interventions in Parkinson’s disease: viral induction of a slow-progressing motor phenotype, dopaminergic degeneration and early microglia neuroinflammation

Parkinson’s disease is a chronic progressive neurodegenerative disorder, mostly manifesting in late adulthood. Patients suffering from this idiopathic disease of the nervous system develop cardinal motor symptoms that usually appear after non-motor symptoms. It is characterized by loss of dopaminerg...

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Bibliographic Details
Main Authors: Ekaterini Kefalakes, Franziska J. Mewes, Diana Peristich, Clara Plötner, Volodymyr Shcherbatyy, Julia Schipke, Friederike Schneider, Christopher Käufer, Regina Rumpel
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Brain Research Bulletin
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Online Access:http://www.sciencedirect.com/science/article/pii/S036192302500276X
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