CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC

CAFs-derived lactate enhances the cancer stemness through inhibiting the MST1 ubiquitination degradation in OSCC

Abstract Background Cancer-associated fibroblasts (CAFs), a predominant stromal cell type in the tumor microenvironment, significantly affect the progression of oral squamous cell carcinoma (OSCC). Results The specific mechanisms through which CAFs influence the cancer stem cell phenotype in OSCC ar...

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Bibliographic Details
Main Authors: Shuzhen Zhang, Jingjing Wang, Yang Chen, Weilian Liang, Hanzhe Liu, Ruixue Du, Yunqing Sun, Chuanyu Hu, Zhengjun Shang
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell & Bioscience
Subjects:
Lactate
Cancer stem cells
DLG5
Hippo pathway
Ubiquitination
Online Access:https://doi.org/10.1186/s13578-024-01329-y
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https://doi.org/10.1186/s13578-024-01329-y

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