Community and Universal Testing for TB among close contacts of microbiologically confirmed pulmonary TB patients in two high TB burden countries: a protocol for a pragmatic cluster-randomised control trial

Community and Universal Testing for TB among close contacts of microbiologically confirmed pulmonary TB patients in two high TB burden countries: a protocol for a pragmatic cluster-randomised control trial

Abstract Background Tuberculosis (TB) symptom screening and testing using either smear microscopy or GeneXpert MTB/RIF Ultra (Xpert Ultra) have been the mainstay for diagnosing TB disease in case finding. Reliance on symptom-based TB screening results in missed TB cases, and universal TB testing app...

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Main Authors: Mgcini Moyo, Thobani Ntshiqa, Yohhei Hamada, Andrew Copas, Issa Sabi, Elias Nyanda Ntinginya, Julieth Lalashowi, Manthomeng Matete, Griffiths Kubeka, Lindiwe Tsope, Rachel Mukora, Don Mudzengi, Tanya Nielson, Knut Lönnroth, Stefan Niemann, Molebogeng Rangaka, Kavindhran Velen, Salome Charalambous, Stacie Stender, Lilian Tina Minja
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Trials
Subjects:
Tuberculosis
Universal TB testing
Household contacts
Household contact tracing
TB preventive therapy
Tuberculosis infection
Online Access:https://doi.org/10.1186/s13063-025-08978-5
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https://doi.org/10.1186/s13063-025-08978-5

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