Genomic Medicine in the Developing World: Cancer Spectrum, Cumulative Risk and Survival Outcomes for Lynch Syndrome Variant Heterozygotes with Germline Pathogenic Variants in the <i>MLH1</i> and <i>MSH2</i> Genes

Genomic Medicine in the Developing World: Cancer Spectrum, Cumulative Risk and Survival Outcomes for Lynch Syndrome Variant Heterozygotes with Germline Pathogenic Variants in the <i>MLH1</i> and <i>MSH2</i> Genes

<b>Background</b>: Although genetic testing has improved our ability to diagnose Lynch syndrome (LS), there is still limited information on the extent of variations in the clinical and genetic landscape among LS variant heterozygotes (LSVH) in Africa. We sought to investigate the cancer...

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Bibliographic Details
Main Authors: Lutricia Ndou, Ramadhani Chambuso, Ursula Algar, Adam Boutall, Paul Goldberg, Raj Ramesar
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomedicines
Subjects:
Lynch syndrome registry
colorectal cancer
extracolonic cancer
cumulative risk
genetic variants
crude survival
Online Access:https://www.mdpi.com/2227-9059/12/12/2906
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