Optimization of neuron-specific interfering peptides targeting GABAB receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia

Optimization of neuron-specific interfering peptides targeting GABAB receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia

BackgroundCerebral ischemia triggers a cascade of detrimental events, leading to brain damage mainly due to the over-excitation of neurons. Currently, clinically applicable neuroprotective treatments to stop progressive neuronal death remain elusive. The GABAB receptor, crucial for neuronal inhibiti...

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Bibliographic Details
Main Authors: Mohammad Hleihil, Musadiq A. Bhat, Thomas Grampp, Dietmar Benke
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
GABAB receptor
interfering peptide
cerebral ischemia
neuron-specific targeting
RVG blood brain barrier shuttles (BBBpS)
middle cerebral artery occlusion (MCAO)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1576884/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1576884/full

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