Nature Knows Best: Extracellular Matrix‐Gelatin Hydrogel Masking Bioauthentic Bone Scaffold Locking Blood Clot to Induce M2 Macrophage‐Mediated Bone Regeneration via Activating an Endocytosis‐Macroautophagy‐Inflammation Axis

Nature Knows Best: Extracellular Matrix‐Gelatin Hydrogel Masking Bioauthentic Bone Scaffold Locking Blood Clot to Induce M2 Macrophage‐Mediated Bone Regeneration via Activating an Endocytosis‐Macroautophagy‐Inflammation Axis

Individualized biological hydroxyapatite (BHA) scaffolds are essential for repairing critical craniomaxillofacial bone defects. Additive manufacturing relies on synthetic hydroxyapatite and biomimetic structures, making the resulting scaffolds inferior to natural bone. A subtractive manufacturing so...

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Main Authors: Jieyun Xu, Xiaoran Yu, Hongcheng Chen, Junlong Xue, Zhuohong Gong, Zhengjie Shan, Shijie Chen, Yuanlong Guo, Xiaomeng Gao, Linjun Zhang, Yin Xiao, Feilong Deng, Zetao Chen
Format: Article
Language:English
Published: Wiley-VCH 2025-05-01
Series:Small Structures
Subjects:
bioauthentic bone scaffolds
ectopic bone regeneration
extracellular matrix‐gelatin hydrogel‐masking
locked blood clot
M2 immune microenvironment
Online Access:https://doi.org/10.1002/sstr.202400499
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https://doi.org/10.1002/sstr.202400499

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