Sevoflurane inhibition of the developmentally expressed neuronal sodium channel Nav1.3

Abstract Neuronal voltage-gated sodium channels (Nav) are major targets for the neurophysiological actions of general anesthetics. In the adult brain, cell type-specific effects on synaptic transmission are attributed to the differential sensitivity to volatile anesthetics of specific Nav subtypes p...

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Bibliographic Details
Main Authors: Jiaxin Xiang, Karl F. Herold, Jimcy Platholi, Hugh C. Hemmings
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-15280-6
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