MRO/HNRNPU/CCL5 feedback loop amplifies M2 macrophage and breast cancer cell crosstalk to drive progression

MRO/HNRNPU/CCL5 feedback loop amplifies M2 macrophage and breast cancer cell crosstalk to drive progression

Abstract Background M2 macrophages are known to enhance the malignant phenotype of breast cancer (BC) cells, yet the underlying mechanisms remain unclear. Methods scRNA sequencing analysis, chromatin immunoprecipitation, immunoprecipitation, exosome isolation, and biological experiments were used to...

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Bibliographic Details
Main Authors: Zhirui Zeng, Xin Bao, Shan Lei, Wenjing Tang, Huading Tai, Lu Wang, Dahuan Li, Shu Liu, Tengxiang Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Breast cancer
M2 macrophage
MRO
Feedback loop
Online Access:https://doi.org/10.1186/s12967-025-06776-w
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https://doi.org/10.1186/s12967-025-06776-w

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