Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells

Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells

Abstract Iron is an irreplaceable co-factor for metabolism. Iron deficiency affects >1 billion people and decreased iron availability impairs immunity. Nevertheless, how iron deprivation impacts immune cell function remains poorly characterised. We interrogate how physiologically low iron availab...

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Main Authors: Megan R. Teh, Nancy Gudgeon, Joe N. Frost, Linda V. Sinclair, Alastair L. Smith, Christopher L. Millington, Barbara Kronsteiner, Jennie Roberts, Bryan P. Marzullo, Hannah Murray, Alexandra E. Preston, Victoria Stavrou, Jan Rehwinkel, Thomas A. Milne, Daniel A. Tennant, Susanna J. Dunachie, Andrew E. Armitage, Sarah Dimeloe, Hal Drakesmith
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60204-7
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https://doi.org/10.1038/s41467-025-60204-7

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