Insights into structure and activity of a UDP-GlcNAc 2-epimerase involved in secondary cell wall polymer biosynthesis in Paenibacillus alvei

Insights into structure and activity of a UDP-GlcNAc 2-epimerase involved in secondary cell wall polymer biosynthesis in Paenibacillus alvei

IntroductionS-layer anchoring in Paenibacillus alvei is enabled by a non-covalent interaction between an S-layer homology domain trimer and a secondary cell wall polymer (SCWP), ensuring the structural integrity of the bacterial cell wall. Within the SCWP repeat, pyruvylated ManNAc serves as the lig...

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Bibliographic Details
Main Authors: Cordula Stefanović, Max S. G. Legg, Nick Mateyko, Jakob J. Ender, Tea Kuvek, Chris Oostenbrink, Christina Schäffer, Stephen V. Evans, Fiona F. Hager-Mair
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
glycobiology
kinetic constants
non-hydrolyzing epimerase
Paenibacillus alvei
S-layer anchoring
structure-activity relationship
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1470989/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2024.1470989/full

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