In-depth patient-specific analysis of tumor heterogeneity in melanoma brain metastasis: Insights from spatial transcriptomics and multi-region bulk sequencing

In-depth patient-specific analysis of tumor heterogeneity in melanoma brain metastasis: Insights from spatial transcriptomics and multi-region bulk sequencing

Melanoma brain metastases (MBM) exhibit extensive intertumor and intratumor heterogeneity (ITH), driven by a complex tumor microenvironment. The aim of this study was to perform a detailed analysis of individual MBM patient tumors using a multiomics approach, integrating spatial transcriptomics with...

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Main Authors: Nidhi Sharma, Jana Rájová, Georgios Mermelekas, Kim Thrane, Joakim Lundeberg, Alia Shamikh, Sofi Vikström, Haris Babačić, Margret Jensdottir, Janne Lehtiö, Maria Pernemalm, Hanna Eriksson
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Translational Oncology
Subjects:
Melanoma brain metastases
Immunotherapy
PD-1
Targeted therapy
Immune signaling
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001998
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