Evaluating the Impact of N-Glycan Sequon Removal in the p27 Peptide on RSV F Protein Immunogenicity and Functionality

Evaluating the Impact of N-Glycan Sequon Removal in the p27 Peptide on RSV F Protein Immunogenicity and Functionality

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children, elderly and immunocompromised patients worldwide. The RSV fusion (F) protein, which has 5–6 N-glycosylation sites depending on the strain, is a major target for vaccine development....

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Bibliographic Details
Main Authors: Lotte Jacobs, Annelies Leemans, Kim Stobbelaar, Axelle Fransen, Paul Cos, Peter Delputte
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Viruses
Subjects:
RSV
fusion protein
p27 peptide
N-glycosylation
DNA immunization
Online Access:https://www.mdpi.com/1999-4915/16/12/1848
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