Perfluorochemical Liquid-Adenovirus Suspensions Enhance Gene Delivery to the Distal Lung

We compared lung delivery methods of recombinant adenovirus (rAd): (1) rAd suspended in saline, (2) rAd suspended in saline followed by a pulse-chase of a perfluorochemical (PFC) liquid mixture, and (3) a PFC-rAd suspension. Cell uptake, distribution, and temporal expression of rAd were examined us...

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Bibliographic Details
Main Authors: Jeffrey A. Kazzaz, Marlene S. Strayer, Jichuan Wu, Daniel J. Malone, Hshi-chi Koo, Thomas H. Shaffer, Jonathan M. Davis, David S. Strayer, Marla R. Wolfson
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Pulmonary Medicine
Online Access:http://dx.doi.org/10.1155/2011/918036
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