Predictors of renal function decline in patients with gastroenteropancreatic neuroendocrine tumors undergoing [177Lu]Lu-DOTA-TATE therapy

Predictors of renal function decline in patients with gastroenteropancreatic neuroendocrine tumors undergoing [177Lu]Lu-DOTA-TATE therapy

Abstract Background Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTA-TATE is an established treatment for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs). While overall renal safety is high, the kidneys remain an organ at risk. This study aimed to determine whether c...

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Main Authors: Felix L. Herr, Christian Dascalescu, Victoria Fusch, Caroline Smith, Ricarda Ebner, Mathias J. Zacherl, Florian Eckenweber, Konrad Klimek, Christoph J. Auernhammer, Christine Spitzweg, Jens Ricke, Maurice M. Heimer, Clemens C. Cyran, Rudolf A. Werner, Gabriel T. Sheikh
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:EJNMMI Research
Subjects:
GEP-NET
[177Lu]Lu-DOTA-TATE
KDIGO 2024
Renal toxicity
Age
Online Access:https://doi.org/10.1186/s13550-025-01305-8
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https://doi.org/10.1186/s13550-025-01305-8

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