Alternative splicing in the RBMXL1 5′-UTR induces uORF-mediated translation control in activated B lymphocytes

Alternative splicing in the RBMXL1 5′-UTR induces uORF-mediated translation control in activated B lymphocytes

Abstract The RNA binding motif X-linked (RBMX) gene plays multiple roles in gene transcription and alternative splicing regulation. Modifications to its expression have been associated with the development of various cancers. In addition to RBMX, there exist several RBMX-like genes (RBMXLs) that hav...

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Bibliographic Details
Main Authors: Sylvain de Breyne, Hélène Polvèche, Didier Auboeuf, Théophile Ohlmann, Henri Gruffat, Evelyne Manet
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
RBMXL1
uORF
Alternative splicing
Translational regulation
Epstein–Barr virus
B lymphocyte activation
Online Access:https://doi.org/10.1038/s41598-025-03274-3
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https://doi.org/10.1038/s41598-025-03274-3

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