Genome-wide interaction association analysis identifies interactive effects of childhood maltreatment and kynurenine pathway on depression

Genome-wide interaction association analysis identifies interactive effects of childhood maltreatment and kynurenine pathway on depression

Abstract Childhood maltreatment stands out as a pivotal risk factor for depression, with gene-by-environment interaction serving as a crucial mechanism. Here we perform genome-wide interaction analyzes of childhood maltreatment in the UK Biobank, integrating methylation evidence through colocalizati...

Full description

Saved in:
Bibliographic Details
Main Authors: Yaoyao Sun, Yundan Liao, Yuyanan Zhang, Zhe Lu, Yuzhuo Ma, Zhewei Kang, Xiaoyang Feng, Guorui Zhao, Junyuan Sun, Yunqing Zhu, Rui Yuan, Yang Yang, Liangkun Guo, Xiao Zhang, Dai Zhang, Runsen Chen, Wenjian Bi, Weihua Yue
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57066-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-025-57066-4

Similar Items