Phospholipase Cζ, the Molecular Spark of Fertilization and Male Infertility: Insights from Bench to Bedside

Phospholipase Cζ, the Molecular Spark of Fertilization and Male Infertility: Insights from Bench to Bedside

Phospholipase C zeta (PLCζ) has emerged as a pivotal sperm-specific factor responsible for triggering oocyte activation, a process essential for successful fertilization and early embryogenesis. A narrative review was conducted to examine the molecular architecture and biochemical features of PLCζ,...

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Bibliographic Details
Main Authors: Aris Kaltsas, Maria-Anna Kyrgiafini, Zissis Mamuris, Fotios Dimitriadis, Athanasios Zachariou, Michael Chrisofos, Nikolaos Sofikitis
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Medicina
Subjects:
phospholipase C zeta
oocyte activation
male infertility
intracytoplasmic sperm injection
globozoospermia
total fertilization failure
Online Access:https://www.mdpi.com/1648-9144/61/6/963
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