Stereotactic body radiation therapy (SBRT) increases anti-PD-1 antitumor activity by enhancing the tumor immune microenvironment in mice with metastatic hepatocellular carcinoma

Stereotactic body radiation therapy (SBRT) increases anti-PD-1 antitumor activity by enhancing the tumor immune microenvironment in mice with metastatic hepatocellular carcinoma

Abstract Background To explore the effect of radiotherapy on anti-pd-1 anti-tumor activity in metastatic hepatocellular carcinoma. Methods Patients with metastatic HCC treated with intensity-modulated radiation therapy (IMRT) in combination with immunotherapy (n = 13) were retrospectively analyzed b...

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Bibliographic Details
Main Authors: Ke Xu, Tao Gu, Ke Su, Xin Liu, Bingsheng He, Jie He, Hao Chi, Xuancheng Zhou, Hanlin Liu, Rui Xiao, Xue Tang, Qinni Ye, Xue Zhou, Yingpeng Liu, Jie Xiong, Pan Wang, Han Li, Kun He, Lu Guo, Yunwei Han
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
Subjects:
Stereotactic body radiation therapy
Tumor immune microenvironment
Immunotherapy
PD-1 antibody
Metastatic hepatocellular carcinoma
Toxic effects.
Online Access:https://doi.org/10.1007/s12672-025-02914-4
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https://doi.org/10.1007/s12672-025-02914-4

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