Targeted NMDA receptor knockdown in recall‐activated neuronal ensembles impairs remote fear extinction

Targeted NMDA receptor knockdown in recall‐activated neuronal ensembles impairs remote fear extinction

Abstract Fear extinction training in rodents decreases fear responses, providing a model for the development of post-traumatic stress disorder therapeutics. Fear memory recall reactivates the consolidated fear memory trace across multiple brain regions, and several studies have suggested that these...

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Bibliographic Details
Main Authors: Yongmin Sung, Dae Hee Han, Junhyuk Kim, Pojeong Park, Bong-Kiun Kaang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Brain
Subjects:
Remote fear memory extinction
Recall-activated neurons
N-methyl-d-aspartate receptors
Clustered regularly interspaced short palindromic repeats (CRISPR)
Online Access:https://doi.org/10.1186/s13041-025-01203-z
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https://doi.org/10.1186/s13041-025-01203-z

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