Correlation Between Interleukin IL-6/IL-6 Receptor Polymorphisms (<i>IL6</i>–174C>G and <i>IL6R</i> 1073A>C) and RAS/BRAF Mutations in Patients with Colorectal Cancer

Correlation Between Interleukin IL-6/IL-6 Receptor Polymorphisms (<i>IL6</i>–174C>G and <i>IL6R</i> 1073A>C) and RAS/BRAF Mutations in Patients with Colorectal Cancer

Background: Chronic inflammation is an important factor in the development and progression of colorectal cancer (CRC). One of the key participants of chronic inflammation is interleukin-6 (IL-6), which enhances tumor malignancy. Some of the genetic markers characterizing the IL-6/STAT3/JAK pathway a...

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Bibliographic Details
Main Authors: Ekaterina Smagina, Dar’ya Polit’ko, Vadim Kumeiko, Lyudmila Gurina, Anna Stenkova
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Gastroenterology Insights
Subjects:
colorectal cancer
IL-6/JAK/STAT3 pathway
IL-6
IL-6R
genotyping
Online Access:https://www.mdpi.com/2036-7422/16/1/6
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