Glioma promotes macrophage immunosuppressive phenotype through ANXA1 in a methionine metabolism-dependent manner
Abstract In gliomas, particularly in glioblastoma (GBM), the tumor immunosuppressive microenvironment is widely recognized as a significant obstacle to effective treatment, contributing to reduced survival rates and the failure of targeted therapies and chemotherapy. Methionine (Met) is an essential...
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| Main Authors: | Hong Hu, Yishuai Huang, Jiafeng Li, Ruijie Liu, Honglei Li, Meng Cai, Hao Chen, Ning Wang, Shuo Yang, Kaikai Wang, Lei Teng, Huailei Liu |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-07-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-03112-y |
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