Glioma promotes macrophage immunosuppressive phenotype through ANXA1 in a methionine metabolism-dependent manner

Abstract In gliomas, particularly in glioblastoma (GBM), the tumor immunosuppressive microenvironment is widely recognized as a significant obstacle to effective treatment, contributing to reduced survival rates and the failure of targeted therapies and chemotherapy. Methionine (Met) is an essential...

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Bibliographic Details
Main Authors: Hong Hu, Yishuai Huang, Jiafeng Li, Ruijie Liu, Honglei Li, Meng Cai, Hao Chen, Ning Wang, Shuo Yang, Kaikai Wang, Lei Teng, Huailei Liu
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
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Online Access:https://doi.org/10.1007/s12672-025-03112-y
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