ADAMTS7, a target in atherosclerosis, cooperates with its homolog ADAMTS12 to protect against myxomatous valve degeneration

ADAMTS7, a target in atherosclerosis, cooperates with its homolog ADAMTS12 to protect against myxomatous valve degeneration

The physiological roles of the metalloprotease-proteoglycan ADAMTS7, a drug target in atherosclerosis and vascular restenosis, and its homolog ADAMTS12, are undefined in the cardiovascular system. The objective of the present work was to investigate their roles in mice with genetic inactivation of b...

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Main Authors: Timothy J. Mead, Sumit Bhutada, Niccolò Peruzzi, Janet Adegboye, Deborah E. Seifert, Elisabeth Cahill, Jeanne Drinko, Eoin Donnellan, Anu Guggiliam, Zoran Popovic, Brian Griffin, Karin Tran-Lundmark, Suneel S. Apte
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
ADAMTS
Extracellular matrix
Metalloproteinase
Proteoglycan
Myxomatous valve
Heart valve
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976125000078
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