PKMζ drives spatial memory reconsolidation but not maintenance

PKMζ drives spatial memory reconsolidation but not maintenance

Non-reinforced reactivation destabilizes spatial memory in the Morris water maze (MWM), triggering reconsolidation, a protein synthesis-dependent process that restabilizes reactivated memories. PKMζ is a constitutively active, atypical PKC isoform implicated in memory storage. However, the potential...

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Bibliographic Details
Main Authors: João Rodrigo de Oliveira, Janine I. Rossato, Johseph P. G. Souza, Rodrigo Orvate, Livia Carneiro, Ana Luizi Baracho, Martín Cammarota
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
hippocampus
PKMζ
reconsolidation
spatial memory
memory maintenance
amnesia
Online Access:https://www.frontiersin.org/articles/10.3389/fnsyn.2025.1638371/full
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https://www.frontiersin.org/articles/10.3389/fnsyn.2025.1638371/full

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