Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report
A 55-year-old female patient affected by an EGFR mutant NSCLC with multiple lytic bone metastases and two prior pathological fractures, undergoing treatment with osimertinib and denosumab, participated in a 9-month physical exercise program. The exercise program was performed twice a week and consis...
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025011491 |
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| author | Anita Borsati Christian Ciurnelli Lorenzo Belluomini Marco Sposito Jessica Insolda Linda Toniolo Ilaria Trestini Daniela Tregnago Michele Milella Federico Schena Sara Pilotto Alice Avancini |
| author_facet | Anita Borsati Christian Ciurnelli Lorenzo Belluomini Marco Sposito Jessica Insolda Linda Toniolo Ilaria Trestini Daniela Tregnago Michele Milella Federico Schena Sara Pilotto Alice Avancini |
| author_sort | Anita Borsati |
| collection | DOAJ |
| description | A 55-year-old female patient affected by an EGFR mutant NSCLC with multiple lytic bone metastases and two prior pathological fractures, undergoing treatment with osimertinib and denosumab, participated in a 9-month physical exercise program. The exercise program was performed twice a week and consisted of aerobic and strength training. Aerobic training was composed of moderate-intensity continuous training for the first 3 months and then high-intensity interval training. Strength training was performed through body-weight/elastic band exercises for the first 6 months and isotonic machines from months 6–9. Assessments, performed every 3 months, included physical fitness parameters, such as functional capacity, muscle strength, anthropometric measures, body composition, and quality of life. Functional capacity progressively improved by 80 m at month 6 and slightly decreased by 22 m at month 9. At the end of the intervention, grip strength increased in both arms, whereas the body composition showed a progressive decrease in fat mass (−3.39 kg) and an increase in muscle mass (+3.89 kg) until month 6 and then stabilization. Quality of life exhibits a great improvement in the first 3 months, especially in the physical role, emotional functioning, fatigue, pain, dyspnoea, insomnia, appetite loss, constipation, and diarrhea, and then maintained with little variations. This case suggests that a highly structured physical exercise program may be feasible, safe, and effective in patients with lung cancer and bone metastases if performed under the supervision of trained experts. |
| format | Article |
| id | doaj-art-4e9cf8bd495d4e51b7a2e9d7847205c7 |
| institution | DOAJ |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-4e9cf8bd495d4e51b7a2e9d7847205c72025-08-20T03:00:31ZengElsevierHeliyon2405-84402025-02-01114e4276810.1016/j.heliyon.2025.e42768Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case reportAnita Borsati0Christian Ciurnelli1Lorenzo Belluomini2Marco Sposito3Jessica Insolda4Linda Toniolo5Ilaria Trestini6Daniela Tregnago7Michele Milella8Federico Schena9Sara Pilotto10Alice Avancini11Department of Medicine, University of Verona, Italy; Department of Neurosciences, Biomedicine and Movement, University of Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement, University of Verona, ItalySection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, ItalySection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, ItalySection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement, University of Verona, ItalyDietetic Service, Medical Direction, University Hospital of Verona (AOUI), ItalySection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, ItalySection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement, University of Verona, ItalySection of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, Italy; Corresponding author. Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, P. le L.A. Scuro 10, 37134, Verona, Italy.Section of Innovation Biomedicine - Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, ItalyA 55-year-old female patient affected by an EGFR mutant NSCLC with multiple lytic bone metastases and two prior pathological fractures, undergoing treatment with osimertinib and denosumab, participated in a 9-month physical exercise program. The exercise program was performed twice a week and consisted of aerobic and strength training. Aerobic training was composed of moderate-intensity continuous training for the first 3 months and then high-intensity interval training. Strength training was performed through body-weight/elastic band exercises for the first 6 months and isotonic machines from months 6–9. Assessments, performed every 3 months, included physical fitness parameters, such as functional capacity, muscle strength, anthropometric measures, body composition, and quality of life. Functional capacity progressively improved by 80 m at month 6 and slightly decreased by 22 m at month 9. At the end of the intervention, grip strength increased in both arms, whereas the body composition showed a progressive decrease in fat mass (−3.39 kg) and an increase in muscle mass (+3.89 kg) until month 6 and then stabilization. Quality of life exhibits a great improvement in the first 3 months, especially in the physical role, emotional functioning, fatigue, pain, dyspnoea, insomnia, appetite loss, constipation, and diarrhea, and then maintained with little variations. This case suggests that a highly structured physical exercise program may be feasible, safe, and effective in patients with lung cancer and bone metastases if performed under the supervision of trained experts.http://www.sciencedirect.com/science/article/pii/S2405844025011491Physical activityBone metastasisLung cancerSafetyBone-targeted agents |
| spellingShingle | Anita Borsati Christian Ciurnelli Lorenzo Belluomini Marco Sposito Jessica Insolda Linda Toniolo Ilaria Trestini Daniela Tregnago Michele Milella Federico Schena Sara Pilotto Alice Avancini Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report Heliyon Physical activity Bone metastasis Lung cancer Safety Bone-targeted agents |
| title | Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report |
| title_full | Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report |
| title_fullStr | Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report |
| title_full_unstemmed | Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report |
| title_short | Combining a 9-month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced NSCLC with multiple osteolytic bone lesions: A case report |
| title_sort | combining a 9 month tailored physical exercise program with osimertinib and denosumab in a patient affected by advanced nsclc with multiple osteolytic bone lesions a case report |
| topic | Physical activity Bone metastasis Lung cancer Safety Bone-targeted agents |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025011491 |
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