Characterization of vanA-harboring plasmids supports differentiation of outbreak-related and sporadic vancomycin-resistant Enterococcus faecium isolates in a tertiary care hospital

Characterization of vanA-harboring plasmids supports differentiation of outbreak-related and sporadic vancomycin-resistant Enterococcus faecium isolates in a tertiary care hospital

Abstract Background The prevention of vancomycin-resistant Enterococcus faecium (VREfm) infections and transmissions poses a major challenge to hospitals. Vancomycin resistance can be plasmid encoded; however, as the analysis of plasmids is challenging, so far only a few reports have provided a deta...

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Bibliographic Details
Main Authors: A. Sobkowiak, N. Scherff, V. van Almsick, F. Schuler, T. J. Brix, A. Mellmann, V. Schwierzeck
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Microbiology
Subjects:
Vancomycin-resistant Enterococcus faecium (VREfm)
Molecular surveillance
Long-read whole genome sequencing (lrWGS)
Plasmid
vanA
Transmission
Online Access:https://doi.org/10.1186/s12866-025-04058-5
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https://doi.org/10.1186/s12866-025-04058-5

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