Mechanism of action of Salvia miltiorrhiza on avascular necrosis of the femoral head determined by integrated network pharmacology and molecular dynamics simulation

Mechanism of action of Salvia miltiorrhiza on avascular necrosis of the femoral head determined by integrated network pharmacology and molecular dynamics simulation

Abstract Avascular necrosis of the femoral head (ANFH) is a progressive, multifactorial, and challenging clinical condition that often leads to hip dysfunction and deterioration. The pathogenesis of ANFH is complex, and there is no foolproof treatment strategy. Although some pharmacologic and surgic...

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Bibliographic Details
Main Authors: Xiangjin Wang, Lijiao Wu, Dan Luo, Langyu He, Hao Wang, Bo Peng
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Avascular necrosis of the femoral head
Salviae Miltiorrhiz
Network pharmacology
Molecular docking
Molecular dynamics
Online Access:https://doi.org/10.1038/s41598-024-79532-7
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https://doi.org/10.1038/s41598-024-79532-7

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