Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model
Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/379360 |
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| _version_ | 1849405396887797760 |
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| author | Lyudmil Terziev Violeta Dancheva Veneta Shopova Galya Stavreva |
| author_facet | Lyudmil Terziev Violeta Dancheva Veneta Shopova Galya Stavreva |
| author_sort | Lyudmil Terziev |
| collection | DOAJ |
| description | Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate. Results. The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2. Conclusions. The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model. |
| format | Article |
| id | doaj-art-4e59fc4cabce4548bbb0eef4e1710eee |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4e59fc4cabce4548bbb0eef4e1710eee2025-08-20T03:36:41ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/379360379360Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice ModelLyudmil Terziev0Violeta Dancheva1Veneta Shopova2Galya Stavreva3Sector of Clinical Immunology and Allergology, Pelven Medical University, 5800 Pleven, BulgariaSector of Disaster Medicine, Pelven Medical University, 5800 Pleven, BulgariaSector of Disaster Medicine, Pelven Medical University, 5800 Pleven, BulgariaSector of Clinical and Experimental Pharmacology, Pelven Medical University, 5800 Pleven, BulgariaAim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate. Results. The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2. Conclusions. The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model.http://dx.doi.org/10.1100/2012/379360 |
| spellingShingle | Lyudmil Terziev Violeta Dancheva Veneta Shopova Galya Stavreva Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model The Scientific World Journal |
| title | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
| title_full | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
| title_fullStr | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
| title_full_unstemmed | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
| title_short | Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model |
| title_sort | antioxidant effect of mnte 2 pyp on lung in asthma mice model |
| url | http://dx.doi.org/10.1100/2012/379360 |
| work_keys_str_mv | AT lyudmilterziev antioxidanteffectofmnte2pyponlunginasthmamicemodel AT violetadancheva antioxidanteffectofmnte2pyponlunginasthmamicemodel AT venetashopova antioxidanteffectofmnte2pyponlunginasthmamicemodel AT galyastavreva antioxidanteffectofmnte2pyponlunginasthmamicemodel |