17β-Estradiol Promotes Tumorigenicity Through an Autocrine AREG/EGFR Loop in ER-α-Positive Breast Cancer Cells

17β-Estradiol Promotes Tumorigenicity Through an Autocrine AREG/EGFR Loop in ER-α-Positive Breast Cancer Cells

We previously reported that the level of EGFR expression is directly associated with the survival rate of estrogen receptor-positive (ER+) breast cancer patients. Here, we investigated how ER activation by 17β-estradiol (E2), the most potent form of estrogen, affects the expression or activity of EG...

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Bibliographic Details
Main Authors: Sun Young Yoon, Yisun Jeong, Jai Min Ryu, Se Kyung Lee, Byung Joo Chae, Jonghan Yu, Seok Won Kim, Seok Jin Nam, Sangmin Kim, Jeong Eon Lee
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
AREG
EGFR
ER
prognosis
targeted therapy
Online Access:https://www.mdpi.com/2073-4409/14/10/703
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