Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition

Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition

Abstract Outer membrane proteins (OMPs) produced by Gram-negative bacteria contain a cylindrical amphipathic β-sheet (“β-barrel”) that functions as a membrane spanning domain. The assembly (folding and membrane insertion) of OMPs is mediated by the heterooligomeric β-barrel assembly machine (BAM). T...

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Main Authors: Morgan E. Walker, Wei Zhu, Janine H. Peterson, Hao Wang, Jon Patteson, Aileen Soriano, Han Zhang, Todd Mayhood, Yan Hou, Samaneh Mesbahi-Vasey, Meigang Gu, John Frost, Jun Lu, Jennifer Johnston, Christopher Hipolito, Songnian Lin, Ronald E. Painter, Daniel Klein, Abbas Walji, Adam Weinglass, Terri M. Kelly, Adrian Saldanha, Jeffrey Schubert, Harris D. Bernstein, Scott S. Walker
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58086-w
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https://doi.org/10.1038/s41467-025-58086-w

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