Late and Chronic Antibody-Mediated Rejection: Main Barrier to Long Term Graft Survival
Antibody-mediated rejection (AMR) is an important cause of graft loss after organ transplantation. It is caused by anti-donor-specific antibodies especially anti-HLA antibodies. C4d had been regarded as a diagnosis marker for AMR. Although most early AMR episodes can be successfully controlled or re...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/859761 |
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| _version_ | 1832556885548466176 |
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| author | Qiquan Sun Yang Yang |
| author_facet | Qiquan Sun Yang Yang |
| author_sort | Qiquan Sun |
| collection | DOAJ |
| description | Antibody-mediated rejection (AMR) is an important cause of graft loss after organ transplantation. It is caused by anti-donor-specific antibodies especially anti-HLA antibodies. C4d had been regarded as a diagnosis marker for AMR. Although most early AMR episodes can be successfully controlled or reversed, late and chronic AMR remains the leading cause of late graft loss. The strategies which work in early AMR have limited effect on late/chronic episodes. Here, we reviewed the lines of evidence that late/chronic AMR is the leading cause of late graft loss, characteristics of late AMR, and current strategies in managing late/chronic AMR. More effort should be put on the management of late/chronic AMR to make a better long term graft survival. |
| format | Article |
| id | doaj-art-4e02c4916cf2486f881b1a452ef5df1a |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-4e02c4916cf2486f881b1a452ef5df1a2025-02-03T05:44:14ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/859761859761Late and Chronic Antibody-Mediated Rejection: Main Barrier to Long Term Graft SurvivalQiquan Sun0Yang Yang1Department of Renal Transplantation, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, ChinaDepartment of Liver Transplantation, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, ChinaAntibody-mediated rejection (AMR) is an important cause of graft loss after organ transplantation. It is caused by anti-donor-specific antibodies especially anti-HLA antibodies. C4d had been regarded as a diagnosis marker for AMR. Although most early AMR episodes can be successfully controlled or reversed, late and chronic AMR remains the leading cause of late graft loss. The strategies which work in early AMR have limited effect on late/chronic episodes. Here, we reviewed the lines of evidence that late/chronic AMR is the leading cause of late graft loss, characteristics of late AMR, and current strategies in managing late/chronic AMR. More effort should be put on the management of late/chronic AMR to make a better long term graft survival.http://dx.doi.org/10.1155/2013/859761 |
| spellingShingle | Qiquan Sun Yang Yang Late and Chronic Antibody-Mediated Rejection: Main Barrier to Long Term Graft Survival Clinical and Developmental Immunology |
| title | Late and Chronic Antibody-Mediated Rejection: Main Barrier to Long Term Graft Survival |
| title_full | Late and Chronic Antibody-Mediated Rejection: Main Barrier to Long Term Graft Survival |
| title_fullStr | Late and Chronic Antibody-Mediated Rejection: Main Barrier to Long Term Graft Survival |
| title_full_unstemmed | Late and Chronic Antibody-Mediated Rejection: Main Barrier to Long Term Graft Survival |
| title_short | Late and Chronic Antibody-Mediated Rejection: Main Barrier to Long Term Graft Survival |
| title_sort | late and chronic antibody mediated rejection main barrier to long term graft survival |
| url | http://dx.doi.org/10.1155/2013/859761 |
| work_keys_str_mv | AT qiquansun lateandchronicantibodymediatedrejectionmainbarriertolongtermgraftsurvival AT yangyang lateandchronicantibodymediatedrejectionmainbarriertolongtermgraftsurvival |