Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals
The objective of this study was to assess the profile of a variety of dosing regimens for common intravenous antibiotics against contemporary Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa isolates collected in Canada during 2009, using pharmacodynamic model...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2011/971701 |
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| author | Rebecca A. Keel George G. Zhanel Sheryl Zelenitsky David P. Nicolau |
| author_facet | Rebecca A. Keel George G. Zhanel Sheryl Zelenitsky David P. Nicolau |
| author_sort | Rebecca A. Keel |
| collection | DOAJ |
| description | The objective of this study was to assess the profile of a variety of dosing regimens for common intravenous antibiotics against contemporary Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa isolates collected in Canada during 2009, using pharmacodynamic modelling techniques. Monte Carlo simulation was conducted for standard and/or prolonged infusion regimens of cefepime, ceftazidime, ceftriaxone, ciprofloxacin, doripenem, ertapenem, meropenem and piperacillin/tazobactam. The cumulative fraction of response (CFR) was calculated using bactericidal targets for each regimen against each species. All cefepime, doripenem, ertapenem and meropenem regimens achieved optimal exposures against Enterobacteriaceae, whereas target attainment was organism and dose dependent for the other agents. These results support that the currently recommended antimicrobial dosing regimens generally attain acceptable exposures to achieve the requisite pharmacodynamic targets against the Enterobacteriaceae species; however, they fall short of obtaining optimal bactericidal exposures against P aeruginosa. |
| format | Article |
| id | doaj-art-4de86b9a14ef47a78fbda46bd47a3fb2 |
| institution | Kabale University |
| issn | 1712-9532 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-4de86b9a14ef47a78fbda46bd47a3fb22025-02-03T01:26:42ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322011-01-0122413213610.1155/2011/971701Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian HospitalsRebecca A. Keel0George G. Zhanel1Sheryl Zelenitsky2David P. Nicolau3Center for Anti-Infective Research and Development, Connecticut, USAUniversity of Manitoba, Bannatyne Campus, Winnipeg, Manitoba, USAUniversity of Manitoba, Bannatyne Campus, Winnipeg, Manitoba, USACenter for Anti-Infective Research and Development, Connecticut, USAThe objective of this study was to assess the profile of a variety of dosing regimens for common intravenous antibiotics against contemporary Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa isolates collected in Canada during 2009, using pharmacodynamic modelling techniques. Monte Carlo simulation was conducted for standard and/or prolonged infusion regimens of cefepime, ceftazidime, ceftriaxone, ciprofloxacin, doripenem, ertapenem, meropenem and piperacillin/tazobactam. The cumulative fraction of response (CFR) was calculated using bactericidal targets for each regimen against each species. All cefepime, doripenem, ertapenem and meropenem regimens achieved optimal exposures against Enterobacteriaceae, whereas target attainment was organism and dose dependent for the other agents. These results support that the currently recommended antimicrobial dosing regimens generally attain acceptable exposures to achieve the requisite pharmacodynamic targets against the Enterobacteriaceae species; however, they fall short of obtaining optimal bactericidal exposures against P aeruginosa.http://dx.doi.org/10.1155/2011/971701 |
| spellingShingle | Rebecca A. Keel George G. Zhanel Sheryl Zelenitsky David P. Nicolau Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals |
| title_full | Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals |
| title_fullStr | Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals |
| title_full_unstemmed | Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals |
| title_short | Pharmacodynamic Profiling of Antimicrobials against Gram-negative Respiratory Isolates from Canadian Hospitals |
| title_sort | pharmacodynamic profiling of antimicrobials against gram negative respiratory isolates from canadian hospitals |
| url | http://dx.doi.org/10.1155/2011/971701 |
| work_keys_str_mv | AT rebeccaakeel pharmacodynamicprofilingofantimicrobialsagainstgramnegativerespiratoryisolatesfromcanadianhospitals AT georgegzhanel pharmacodynamicprofilingofantimicrobialsagainstgramnegativerespiratoryisolatesfromcanadianhospitals AT sherylzelenitsky pharmacodynamicprofilingofantimicrobialsagainstgramnegativerespiratoryisolatesfromcanadianhospitals AT davidpnicolau pharmacodynamicprofilingofantimicrobialsagainstgramnegativerespiratoryisolatesfromcanadianhospitals |