Properties of CD8 T-cell-recognized neoantigens in different tumor types

Properties of CD8 T-cell-recognized neoantigens in different tumor types

Background: Neoantigen-based immunotherapies rely on computational tools predicting peptide immunogenicity based on properties such as its expression level, binding affinity to human leukocyte antigen (HLA), likelihood of proteasomal cleavage and dissimilarity from wild-type peptide. However, curren...

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Bibliographic Details
Main Authors: S.L.C. Ketelaars, M.M. van Buuren, A. Gangaev, N. van Rooij, S. Patiwael, K. Hoefakker, L.F. Fanchi, P. Baas, M. van der Heijden, M. Kok, T.N. Schumacher, P. Kvistborg, J.B.A.G. Haanen
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Immuno-Oncology and Technology
Subjects:
neoantigen immunogenicity
pHLA multimer screen
CD8 T-cell recognition
eluted ligand score
HLA binding affinity
immunodominance hierarchy
Online Access:http://www.sciencedirect.com/science/article/pii/S259001882500022X
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