TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer

TMEM160 inhibits KEAP1 to suppress ferroptosis and induce chemoresistance in gastric cancer

Abstract Chemoresistance is the most significant challenge affecting the clinical efficacy of the treatment of patients with gastric cancer (GC). Here we reported that transmembrane protein 160 (TMEM160) suppressed ferroptosis and induced chemoresistance in GC cells. Mechanistically, TMEM160 recruit...

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Main Authors: Chunye Huang, Qinru Zeng, Jingyi Chen, Qin Wen, Weilun Jin, Xiaofeng Dai, Ruiwen Ruan, Hongguang Zhong, Yang Xia, Zhipeng Wu, Ruixuan Huang, Jianxi Zhang, Yangyang Yao, Li Li, Wan Lei, Jianping Xiong, Jun Deng
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07621-0
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https://doi.org/10.1038/s41419-025-07621-0

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