Retrospective analysis of sex-disaggregated immune responses to ALVAC-HIV and bivalent subtype C gp120/MF59 HIV vaccines

Retrospective analysis of sex-disaggregated immune responses to ALVAC-HIV and bivalent subtype C gp120/MF59 HIV vaccines

IntroductionGenerally, individuals assigned female at birth (AFAB) develop greater immunogenicity to various vaccines than individuals assigned male at birth (AMAB). Little is known about sex-disaggregated immunogenicity to HIV-1 vaccines. We disaggregated immune responses to an experimental HIV vac...

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Main Authors: Cassie G. Ackerley, Srilatha Edupuganti, Chenchen Yu, Alison C. Roxby, Kelly E. Seaton, Linda-Gail Bekker, Mary Allen, Stephen C. DeRosa, Nicole L. Yates, Jack Heptinstall, Nonhlanhla N. Mkhize, Mookho Malahleha, Kathryn Mngadi, Brodie Daniels, Craig Innes, Briana D. Furch, Marguerite Koutsoukos, Guido Ferrari, Lynn Morris, David C. Montefiori, M. Juliana McElrath, Georgia D. Tomaras, Fatima Laher, Zoe Moodie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
sex
immunogenicity
vaccine
HIV
South Africa
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557009/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1557009/full

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