NSC-derived extracellular vesicles-mediates neuronal plasticity enhancement in vascular dementia via transferring miR-210

NSC-derived extracellular vesicles-mediates neuronal plasticity enhancement in vascular dementia via transferring miR-210

Abstract Chronic hypoperfusion-induced neuronal damage is the pathological basis of vascular dementia (VD). Hypoxia enhances the paracrine effects of neural stem cells (NSCs) by promoting neuroprotection and synaptic plasticity, which may be mediated by extracellular vehicles (EVs) secretion. In thi...

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Main Authors: Qunwen Pan, Yan Wang, Zhi Xiang, Yulan Yin, Yuyan Deng, Kesheng Xiao, Xiaobing Xu, Yahong Wang, Ganwen Deng, Xiaoxia Wang, Wangtao Zhong, Xiaotang Ma
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Acta Neuropathologica Communications
Subjects:
Vascular dementia
Neural stem cells
Extracellular vesicles
Hypoxia
Rab27a
Neuronal plasticity
Online Access:https://doi.org/10.1186/s40478-025-02073-1
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https://doi.org/10.1186/s40478-025-02073-1

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